맙소사!뽀로로와친구들이네모가되어버렸다!?게임왕국을초토화시킨네모바이러스를없애기위해‘에디박사’의도움을구하러차원을넘어온게임왕국의집사‘차차아저씨’.그를쫓아온바이러스괴물로인해뽀롱뽀롱마을은위험에빠지고,‘크롱’과‘포비’는네모가되어버리고만다.뽀로로와친구들은게임왕국과뽀롱뽀롱마을을구하기위해,팀뽀로로&팀에디로나뉘어‘에디박사’가발명한컴퓨터백신을가지고바이러스소탕대작전을시작하는데…과연뽀로로와친구들은게임왕국과뽀롱뽀롱마을을지킬수있을까?